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The efficacies of two brands of ivermectin on acarina ticks of cattle were studied in a herd of 12 N'dama crosses at Ijebu – Igbo, Ogun State. All the animals were naturally infested with Boophilus decoloratus,Hyalomma truncatum and Rhipicephalus evertsi. They were randomly divided into three groups of four animals each. Animals in groups A and B were treated with Ivojec® and Ivomec® respectively at a dose of 0.2mg / kg body weight subcutaneously. Animals in group C were left untreated. The animals were observed over a period of 28 days during which the Packed Cell Volume (PCV) values and presence or absence of ticks were determined weekly. By the 7th day post – treatment, all treated animals were free of ticks while untreated animals had tick infestation throughout the course of study. There were significant differences (p