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The extent to which the use of herbal medicine is accepted among the poultry farmers was investigated. Sixty-eight (68) poultry farmers within Iwo local government of Osun-state responded to the structured questionnaire. Primary data generated were analyzed using descriptive statistics. Acceptability of ethno veterinary medicine in poultry farming was not influenced by age, gender, education, production type and experience but by fear of application, awareness, efficacy and availability. Farmers are yet to exploit the use of herbal medicine in poultry production in the local government area so surveyed.