Angiotensin II type 1 receptor (A1166C) gene polymorphism in Egyptian adult hemodialysis patients

Abstract

Background: Genetic variability in the genes of different components of renin-angiotensin system (RAS) is  likely to contribute for its heterogenous association in renal diseased patients. Among the candidate genes of  RAS, angiotensin II type 1 receptor gene polymorphism (AT1R A1166C) seems to be particularly biologically  and clinically relevant to renal diseases.
The aim: This study was to evaluate the association of AT₁R A1166C gene polymorphism in adult Egyptian hemodialysis (HD) patients. Its association with hypertension was also done.
Subjects and methods: The study was conducted on 202 adult Egyptian subjects: 100 controls and 102 HD patients. Determination of this polymorphism was done by PCR/RFLP strategy.
Results: It revealed that HD patients had significantly higher frequency in AC and CC genotypes than controls. But on dividing these patients to normotensive and hypertensive ones, no significant difference in the genotypes was found. The multiple regression analysis revealed no dependent variables on the AT₁R A1166C gene polymorphism.
Conclusion: This study suggested that CC/AC genotype could serve as a predictor of an early endstage renal disease (ESRD) and could, in the future, become an important part of the clinical process of renal risk identification.

KEYWORDS AT₁R gene polymorphism; Hemodialysis; RAS polymorphism