SOCl₂ catalyzed cyclization of chalcones: Synthesis and spectral studies of some bio-potent ¹<i>H</i> pyrazoles

Abstract

Some aryl-aryl ¹H pyrazoles have been synthesised by cyclization of aryl chalcones and hydrazine hydrate in the presence of SOCl₂. The yields of the pyrazoles are more than 85%. These pyrazoles are characterized by their physical constants and spectral data. The infrared, NMR spectral group frequencies of these pyrazolines have been correlated with Hammett substituent constants, F and R parameters. From the results of statistical analyses the effects of substituent on the spectral frequencies have been studied. The antimicrobial activities of all synthesised pyrazolines have been studied using Bauer-Kirby method.

KEY WORDS: SOCl₂, ¹H Pyrazolines, IR spectra, NMR spectra, Hammett substituent constants, Antimicrobial activities

Bull. Chem. Soc. Ethiop. 2014, 28(2), 271-288.  

DOI: http://dx.doi.org/10.4314/bcse.v28i2.11