Metal complexes of salicylhydroxamic acid and 1,10-phen-anthroline; equilibrium and antimicrobial activity studies

Abstract

Salicylhydroxamic acid and its binary and ternary copper(II), nickel(II), and iron(III) complexes involving 1,10-phenanthroline were studied pH-potentiometrically in 0.15 mol.L^-1 NaNO₃ aqueous solutions at 37 ^oC. The protonation constants of salicylhydroxamic acid and 1,10-phenanthroline as well their binary and mixed ligand complex species stability constants were determined based on 3 estimation models (Irving Rossetti, Bjerrum-Calvin and Hyperquad 2008). Also, six solid complexes were synthesized and their biological activities were evaluated against some pathogenic bacteria and fungi organisms.

KEY WORDS: Salicylhydroxamic acid, 1,10-Phenanthroline, Potentiometry, Antifungal and antibacterial activities

Bull. Chem. Soc. Ethiop. 2014, 28(3), 393-402.

DOI: http://dx.doi.org/10.4314/bcse.v28i3.8