Long-term anti-diabetic and anti-hyperlipidaemic effects of aqueous stem bark extract of <i>Irvingia gabonensis</i> in streptozotocin-induced diabetic rats

Abstract

Irvingia gabonensis is used traditionally to treat diabetes. The antidiabetic effect of the seed extract has been demonstrated in human and animal models. This study was designed to evaluate the long-term antidiabetic
and anti-hyperlipidaemic effects of aqueous stem bark extract of I. gabonensis in streptozotocin-induced diabetic rats. Twenty four Wistar rats in three groups, normal control, diabetic control and I. gabonensis treated
diabetic rats (TDR) were used for this study. Diabetes was induced in 16 rats by intraperitoneal injection of streptozotocin (STZ) at 65mg/kg body weight. Upon confirmation of diabetes, the treated diabetic rats were orally
(by gavage) given aqueous extract of I. gabonensis bark at 200 mg/kg body weight daily for 24 weeks. Body weight was monitored weekly, while fasting blood sugar (FBS) and serum lipid profile (triglycerides, total cholesterol, LDLcholesterol and HDL-cholesterol) were assessed at specific intervals for 24 weeks. I. gabonensis significantly (P<0.05) reduced the FBS of the treated diabetic rats to normal control levels 2 weeks after the commencement of treatment. The reduction of FBS was sustained till the end of the study (24 weeks). Furthermore, at various stages of monitoring, the extract reduced the STZ-induced elevation of serum triglycerides, total cholesterol and LDLcholesterol, and significantly (p<0.05) increased the STZ-induced decrease in HDL-cholesterol. Our study concludes that aqueous stem bark extract of I. gabonensis possess significant long-term anti-diabetic and hypolipidaemic effects. These anti-hyperlipidaemic effects as well as the presence of phytochemicals with recognizable anti-oxidant
effects will be useful in the treatment of diabetic complications.

KEYWORDS: Irvingia gabonensis, Diabetes mellitus, Anti-diabetic, Anti-hyperlipidaemic, Medicinal plants.