We studied the protective effects of vitamin C against the toxic effects of lindane on the epididymis and vas deferens of male mice. There were four treatments: controls (untreated), lindane (20 mg/kg), lindane plus vitamin C (10 mg/kg) and vitamin C only. Lindane induced histopathological alterations in the epididymis and vas deferens characterized by a reduced epithelium with degenerative changes in the muscular layers and connective tissues, and a lack of spermatozoa in the lumen of both epididymis and vas deferens. These changes were restored towards normalcy by vitamin C. These results suggest that vitamin C has some protective role against lindane toxicity in epididymis and vas deferens of male mice.