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An experiment was carried out to determine the effect of replacing synthetic lysine (SL) with blood meal (BM) on apparent nutrients digestibility and hematological responses of broiler chickens. One hundred and fifty (150) unsexed Anak broiler chicks were used. There were five diets with diet (T1) containing 0.10% SL and without BM as control. Diets 2, 3, 4 and 5 contained 1.0, 2.0, 3.0 and 4.0% BM without SL respectively, representing T2, T3, T4 and T5 in the same order. The experiment was arranged in completely randomized design (CRD) with three replicates per treatment. Each treatment had 30 birds, 10 birds per replicate. Diets were isonitrogenous (23%CP and 20%CP) for starter and finisher phases and isocaloric (11.90MJME/Kg and 12.30MJME/Kg) for starter and finisher phases respectively. At the end of the experiment which lasted for 56 days (28 days for each phase), 4.0% BM significantly (P0.05) different at both phases. There was no mortality recorded in all the dietary groups.