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The relationship between parasitic infections and development of anemia was investigated among pupils of Presbyterian primary school, and Government primary School Akpet Central in Biase Local Government Area, Cross River State of Nigeria. A total of 420 stool and corresponding blood samples were collected and examined for the presence of parasites and anemia respectively. The stool samples were examined using the direct smear and floatation techniques while haemoglobin was determined using the cynmethaemoglobin method. The result obtained revealed high prevalence of Plasmodium falciparun (65.0%, 273/420) and intestinal parasites (78.1%, 328/420) with the associated anemia. Ascaris lumbricoides was the commonest parasite seen (71.88%, 230/420), followed closely by hook worm (68.90%, 226/420). Infection with intestinal protozoa was few while no tape worm was seen. There was significant differences (P