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This study investigated the effect of Computer-Mediated Communication Technologies (CMCTS) on user's Job Satisfaction. The Job Description Index (JDI) was used to measure participants' level of Job Satisfaction. A total of 300 participants (186 males, 114 females, 148 CMCTs users, 152 non-users, 141 senior staff and 159 junior staff) drawn from five (5) Organisations in Port Harcourt Nigeria, that use CMCTs were used in the study. The major instrument of data collection was the questionnaire. ANOVA statistics was used for the analysis of data. The study concluded that CMCTs usage has significant impact on Job Satisfaction (P