Five new pyridazine compounds were synthesized. The usefulness of IR, 1HNMR and 13CNMR spectroscopy for the structural analysis of the new compounds is well established. The differences in molecular structure between one absorbing compound and another affected a shift in absorption wavelength (.max). The structure-activity relationship among the pyridazine derivatives was measured against some pathogens. Compound 3e was found to be a more active drug than the standard antibiotic, streptomycin SO4. © 2010 International Formulae Group. All rights reserved.

Keywords: Biological evaluation, novel, pyridazine derivatives, antimicrobial agents.