Treculia africana was claimed to be useful in the treatment of mental illness. The present work was carried out to evaluate the neurobiology and analgesic properties of Treculia africana in mice. The neurobiology and analgesic properties of Treculia africana was investigated by using head dip, elevated plus maze, Y-maze, tail immersion and acetic acid-induced abdominal constriction tests in mice. The results showed that Treculia africana reduced head dips, produced anxiogenic effect, reduced locomotor activity without effect on learning and memory and produced analgesic effect peripherally. It was concluded that Treculia africana possessed sedative and strong analgesic properties. © 2010 International Formulae Group. All rights reserved.

Keywords: Head dip, elevated plus maze, Y-Maze, tail immersion, abdominal constriction