Isolation of Diterpenoids from <i>Jatropha podagrica</i> against Hepatitis C virus

Abstract

One new lathyrane diterpenoid, Jatropodagrene (1) along with three known compounds have been isolated from the root bark of Jatropha podagrica. The structure of the new compound was established from its 1D and 2D NMR spectra and in comparison with data reported in previous literatures. Compound 1 was highly cytotoxic (98.86% inhibition) to the HCV virus, while compounds 2 (EC₅₀, EC₉₀, CC₅₀ 5.8, 33.1, 22.6 μg/mL, respectively) and 3 displayed significant anti HCV activity. This is the first report of the anti hepatitis C virus activity of lathyrane skeleton and J. podagrica.

Keywords: Jatropha podagrica; medicinal plant; hepatitis C virus; extract; pure compounds