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Synthesis and spectroscopic analysis of Schiff Bases of Imesatin and Isatin derivatives


Olubunmi S. Oguntoye
Abdulmumeen A. Hamid
Gabriel S. Iloka
Sunday O. Bodede
Samson O. Owalude
Adedibu C. Tella

Abstract

A series of new Schiff bases of Imesatin and Isatin derivatives which have been previously prepared from the reaction of Hydrazine monohydrate, p-phenylenediamine and 4,4- diaminodiphenylmethane with Isatin were reported. The compounds were characterized by elemental analyses, UV-visible, Infrared and Nuclear Magnetic Resonance (1H NMR and 13C NMR) spectroscopic analyses. The synthesized Schiff bases were obtained in moderate to excellent yields between 55.3 – 89.3%. Infrared spectra of all synthesized compounds contain the characteristic azomethine linkage (-CH=N) between 1580 – 1630 cm-1 and the N–H of the Isatin ring signals between δ 8.32 – 10.68 ppm in their 1H NMR spectra. The present work affords reaction pathway that is efficient and operational simplicity for the synthesis of Schiff bases derivatives.

Keywords: Schiff bases, isatin, imesatin, spectroscopic analysis, biological activity


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eISSN: 2659-1499
print ISSN: 2659-1502