Introduction: Chronic myeloid leukaemia (CML) patients with hyperleukocytosis may demonstrate signs or symptoms of leukostasis including priapism.
Methods: We report two patients with CML who presented with priapism.
Results/Observations: Both cases reported achieved full detumescence after commencing chemotherapy for CML. These cases illustrate the importance of full haematological investigations in patients presenting with priapism in accident and emergency as well as urological emergency clinics.

Key Words: CML, Hyperleukocytosis, leukostasis, priapism