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Glutathione peroxidase activity, lipid peroxidation and the glutathione system were assayed in the lungs, kidneys and brains of 18 month old rats (n=12), who had been on 60% of the caloric intake of the ad-libitum fed rats since 6 weeks of age and also in the control age group of rats (n=12) that were fed ad-libitum.

Lipid peroxidation was markedly lower in the plasma of the caloric restricted group from 16.23+1.53 nmol MDA/ml in the ad-libitum group to 10.34+0.78 nmol MDA/ml (p