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Effects Of Quinghaosu Antimalaria Artemether On Blood Pressure, Heart Rate And Baroflex Sensitivity In Normotensive Rats
CN Anigbogu, OO Osunmakinde
Abstract
The effects of Chronic administration of the new antimalaria drug artemether on cardiovascular function were investigated in albino Sprague-Dawley rats. One group of rats received 3.2mg/kg artemether (Therapeutic dose) and a second group received 18mg/kg of artemether while the control group received vehicle (refined corn oil) for 28 days. The animals were anaesthetized thereafter and cannulated for recording of blood pressure and testing of cardiovascular reflexes.
Results from the study showed that artemether had little or no effect on mean arterial pressure (MAP) both at the therapeutic and high doses compared to the controls (90.37+4.3 and 97.1+2.7mmHg respectively cf 88.35+2.6mmHg, NS). Heart rate (HR) did not change significantly in the artemether treated rats. However during bilateral carotid occlusion (BC)) the magnitude of the change in blood pressure (MAP) and heart rate (HR) were reduced in the group that received 18mg/kg artemether (41.55+2.1mmHg; p
Results from the study showed that artemether had little or no effect on mean arterial pressure (MAP) both at the therapeutic and high doses compared to the controls (90.37+4.3 and 97.1+2.7mmHg respectively cf 88.35+2.6mmHg, NS). Heart rate (HR) did not change significantly in the artemether treated rats. However during bilateral carotid occlusion (BC)) the magnitude of the change in blood pressure (MAP) and heart rate (HR) were reduced in the group that received 18mg/kg artemether (41.55+2.1mmHg; p
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Journal of Medicine and Medical Sciences. ISSN: 1119 - 3999