The anti-ulcer activity of Heinsia crinata, a vegetable, used ethnomedicinally in the treatment of ulcer was evaluated to confirm this claim.The crude ethanolic leaf extract (450 – 1350mg/kg) was investigated against indomethacin, ethanol and histamine – induced ulcer models in rats.The crude leaf extract demonstrated significant (p<0.001) inhibition of ulcer produced by the ulcerogens used; indomethacin, ethanol and histamine.The results of this work confirms the folkloric use of this plant in the treatment of ulcer.

Keywords: Heinsia crinata; Anti-ulcer; Vegetable