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Oxidative stress during the various trimesters of pregnancy in humans was investigated. Venous blood was taken from 30 pregnant women, comprising 10 each at first, second and third trimesters. Additionally, blood was taken from 10 non-pregnant women, and was used as control. The plasma was quickly extracted and assayed for triglyceride, glucose, protein and cholesterol. The plasma lipid peroxidation level and catalase activity were determined. Results of the study showed that the plasma cholesterol and triglyceride levels in the 2nd and 3rd trimesters of pregnancy were significantly (p