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In this study, effect of breadfruit diet on plasma lipids and blood glucose levels in diabetic and normoglycaemic rats were investigated. Forty albino Wistar rats were randomly assigned into 4 groups of ten rats each; the first group (control) fed on normal rat chow. Group 2 received 100% breadfruit diet; group 3 received alloxan treatment (50mg/kg body weight once daily for three days) + normal rat chow and the last group had alloxan treatment along with 100% breadfruit diet. The regimens lasted for a period of 5 weeks. Results on lipid profile (mmol/L) revealed that in normoglycaemic controls, the mean total cholesterol (TC) level was 1.60 ± 0.10; mean triglyceride (TG) was 0.92 ± 0.06; and the mean values of low density lipid (LDL), very low density lipid (VLDL), and high density lipoproteins (HDL) were 0.42 ± .04, 0.58 ± 0.05 and 0.76 ± 0.06 respectively. The blood glucose level (8.40 ± 0.57) in alloxan-induced diabetic rats was significantly higher (P