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The stem of Gongronema latifolium, an edible vegetable, is used by traditional healers in the Western part of Nigeria as part of concoction in the treatment of type 2 diabetes mellitus. The hypoglycaemic and the antihyperglycaemic properties of ethanolic stem extract were studied on normal and alloxan induced diabetic rabbits. Single oral administration of the ethanolic extract to fasted normal rabbits during an oral glucose tolerance test significantly enhanced the clearance of glucose from blood at 500mg/kg and 750mg/kg body weight as compared to the controls(P