Afzelia africana Smith (Caesalpiniaceae) is a perennial tree which occurs in many parts of Africa where it is used as food and widely employed in traditional
medicine practice. Acute toxicity studies in mice established an oral LD50 greater than 5,000 mg/kg for bark methanolic extract. The extract and fractions (5 and 10 mg/ear; 200 and 400 mg/kg) inhibited topical edema induced by xylene in the mouse ear and significantly (P