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Ethanolic leaf-extract of Calotropis procera (CL) was tested for antioxidant properties and hepatoprotective activities (acetaminophen and hepatitis virus induced hepatotoxicity) in albino rats. The antioxidative properties gave total phenolic content (43.79mg/g gallic acid), reducing property (16.67%) and free radical scavenging activity (81.6%). Oral administration of acetaminophen (2g/Kg rat) or intraperitonial administration of 2ml of hepatitis infected serum to the animals caused statistically significant (P