Nigerian Journal of Ophthalmology

Log in or Register to get access to full text downloads.

Remember me or Register

DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

A Review of the Effect of 5-Flurouracil on the Outcome of Trabeculectomy in Ibadan

AM Baiyeroju, JN Ubah


Aim: To retrospectively assess the outcome of trabeculectomy performed using an intraoperative sponge soaked in 5-fluorouracil (50 mg/ml).

Methods: Trabeculectomy with an intraoperative sponge soaked with 5-fluorouracil (5-FU) was performed in 21 eyes of 14 patients. The reduction in intraocular pressure (IOP), complications and variations in visual acuity were noted.

Results: The mean preoperative IOP was 31.5 ± 10.6 mmHg. The mean postoperative IOP was 7.3 ± 5.7mmHg on the second postoperative day and 17.5 ± 9.8mmHg at 3 months. Postoperative complications were mostly transient, with 33% of eyes requiring postoperative antiglaucoma therapy to reduce IOP. Visual acuity improved postoperatively in 3 eyes, worsened in 9 eyes and remained the same in 9 eyes.

Conclusion: Even though a small study, an intraoperative sponge soaked with 5-FU seems to be a safe and effective adjunct to trabeculectomy.
Key Words: 5-flourouracil, trabeculectomy, glaucoma, Nigerian
Nigerian Journal of Ophthalmology Vol.12 (1) 2004: 14-18

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Nigerian Journal of Ophthalmology.   ISSN: 0189-9171
AJOL African Journals Online