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A Review of the Effect of 5-Flurouracil on the Outcome of Trabeculectomy in Ibadan

AM Baiyeroju, JN Ubah

Abstract


Aim: To retrospectively assess the outcome of trabeculectomy performed using an intraoperative sponge soaked in 5-fluorouracil (50 mg/ml).

Methods: Trabeculectomy with an intraoperative sponge soaked with 5-fluorouracil (5-FU) was performed in 21 eyes of 14 patients. The reduction in intraocular pressure (IOP), complications and variations in visual acuity were noted.

Results: The mean preoperative IOP was 31.5 ± 10.6 mmHg. The mean postoperative IOP was 7.3 ± 5.7mmHg on the second postoperative day and 17.5 ± 9.8mmHg at 3 months. Postoperative complications were mostly transient, with 33% of eyes requiring postoperative antiglaucoma therapy to reduce IOP. Visual acuity improved postoperatively in 3 eyes, worsened in 9 eyes and remained the same in 9 eyes.

Conclusion: Even though a small study, an intraoperative sponge soaked with 5-FU seems to be a safe and effective adjunct to trabeculectomy.
Key Words: 5-flourouracil, trabeculectomy, glaucoma, Nigerian
Nigerian Journal of Ophthalmology Vol.12 (1) 2004: 14-18




http://dx.doi.org/10.4314/njo.v12i1.11939

Nigerian Journal of Ophthalmology.   ISSN: 0189-9171