Summary: In this study, the comparative effects of half, normal and double clinical doses of artesunate; artesunate/sulfadoxine/pyrimethamine; artesunate/amodiaquine and their combinants (sulfadoxine/pyrimethamine and amodiaquine) on the semen parameters- total sperm count, motility, morphology, debris and premature/primordial cell count of the male guinea-pig were investigated. The agents caused significant (p