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In vitro activity of Aloe extracts against Plasmodium falciparum
RL van Zyl, AM Viljoen
Abstract
The antiplasmodial activity and toxicity data of 34 Aloe species and their
main constituents were determined. A number of the methanol extracts possessed
antimalarial activity where 50% of the parasite growth was inhibited (IC50 value) by 32 to 77µg ml-1 of the extract. The chemical common to the
most active species is the anthrone C-glucoside homonataloin which inhibited
the chloroquine-resistant Plasmodium falciparum strain with an IC50 value of
13.46 ± 1.36µg ml-1. Homonataloin was a more potent inhibitor
of parasite growth than aloin (IC50 value of 107.20 ± 4.14µg ml-1).
The Aloe extracts tested did not exhibit any toxicity towards transformed human
kidney epithelium cells at the concentrations (0.5–50µg ml-1) used
in the antimalarial assay.
South African Journal of Botany 2002, 68: 106–110
main constituents were determined. A number of the methanol extracts possessed
antimalarial activity where 50% of the parasite growth was inhibited (IC50 value) by 32 to 77µg ml-1 of the extract. The chemical common to the
most active species is the anthrone C-glucoside homonataloin which inhibited
the chloroquine-resistant Plasmodium falciparum strain with an IC50 value of
13.46 ± 1.36µg ml-1. Homonataloin was a more potent inhibitor
of parasite growth than aloin (IC50 value of 107.20 ± 4.14µg ml-1).
The Aloe extracts tested did not exhibit any toxicity towards transformed human
kidney epithelium cells at the concentrations (0.5–50µg ml-1) used
in the antimalarial assay.
South African Journal of Botany 2002, 68: 106–110
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South African Journal of Botany. ISSN: 0254-6299