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Bioactive sesquiterpene lactones isolated from the shoots of Arctotis arctotoides
N Sultana, AJ Afolayan
Abstract
Arctotis arctotoides is
a perennial herb used medicinally for the treatment of various ailments in
the Eastern Cape, South Africa. The n-hexane extract from the shoots of the
herb showed antimicrobial activity against Bacillus subtilis. Bioassay
guided fractionation of the extract has led to the isolation of two known
sesquiterpene lactones, 4β, 15-dihydro-3-dehydro-zaluzanin C and dehydrobrachylaenolide.
The structures of the compounds were elucidated by extensive use of 1Dand
2D-NMR (1H-1H COSY, HMQC, HMBC) studies. The antibacterial activity of the
two compounds was demonstrated using bioautographic assay on TLC plates.
The two compounds showed significant antibacterial activity against Bacillus
subtilis, a Gram-positive bacterium.
South African Journal of Botany 2002, 69(2): 158–160
a perennial herb used medicinally for the treatment of various ailments in
the Eastern Cape, South Africa. The n-hexane extract from the shoots of the
herb showed antimicrobial activity against Bacillus subtilis. Bioassay
guided fractionation of the extract has led to the isolation of two known
sesquiterpene lactones, 4β, 15-dihydro-3-dehydro-zaluzanin C and dehydrobrachylaenolide.
The structures of the compounds were elucidated by extensive use of 1Dand
2D-NMR (1H-1H COSY, HMQC, HMBC) studies. The antibacterial activity of the
two compounds was demonstrated using bioautographic assay on TLC plates.
The two compounds showed significant antibacterial activity against Bacillus
subtilis, a Gram-positive bacterium.
South African Journal of Botany 2002, 69(2): 158–160
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South African Journal of Botany. ISSN: 0254-6299