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Rapidly progressive post-transplant lymphoproliferative disease following withdrawal of sirolimus


M Mendelson
Z Barday
R Eastman
D Le Feuvre
S Candy
H Wu
C Swanepoel

Abstract

Sirolimus, a potent inhibitor of B- and T-cell activation, is a commonly used immunosuppressant after renal transplantation. Withdrawal of sirolimus from the immunosuppression regimen may reduce B-cell surveillance. We present a case of rapidly progressive central nervous system (CNS) polymorphic Epstein-Barr virus (EBV)-related post-transplant lymphoproliferative disorder following the withdrawal of sirolimus.

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eISSN: 2078-5135
print ISSN: 0256-9574