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Antifibrinolytic drugs for acute traumatic injury


M McCaul
T Kredo

Abstract

In South Africa, trauma is a major concern, with violence and road traffic accidents being the fifth and seventh leading causes of death, respectively. Antifibrinolytic agents have been used in trauma and major surgery to prevent fibrinolysis and reduce blood loss. We highlight an updated Cochrane review investigating the effect of antifibrinolytic drugs in patients with acute traumatic injury. The review authors conducted  comprehensive literature searches in January 2015 with regard to all randomised  controlled trials comparing antifibrinolytic agents after acute traumatic injury. Three randomised controlled trials, of which two (n=20 451) assessed the effect of  tranexamic acid (TXA), were included. The authors concluded that TXA safely reduces  mortality in trauma with bleeding without increasing the risk of adverse events. TXA should be administered as early as possible, and within 3 hours of injury. There is still uncertainty with regard to the effect of TXA on patients with traumatic brain injury; however, ongoing randomised controlled trials should shed more light on this.

Journal Identifiers


eISSN: 2078-5135
print ISSN: 0256-9574