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CRISPR-Cas: Revolutionising genome engineering


S.A. Nicholson
M.S. Pepper

Abstract

The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future. This article discusses recent advancements in the technology called ‘clustered regularly interspaced palindromic repeat (CRISPR)-associated genes’ (CRISPR-Cas), the potential of CRISPR-Cas to revolutionise molecular medicine, and the ethical and regulatory hurdles facing its application.


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eISSN: 2078-5135
print ISSN: 0256-9574