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Test of endothelial monolayer integrity in the presence or absence of endotoxin and anti-tnf-a monoclonal antibodies
Andualem Mossie, Stefan Eriksson, Hassen Taha Sherief, Legesse Zerihun
Abstract
Monolayer cultures of human umbilical vein endothelial cells were established and tested for the effects of endotoxin treatment and anti-TNF-a monoclonal antibodies following endotoxin treatment on albumin permeability and electrical conductance. Application of 40 -g(ml)-1 of endotoxin on human umbilical cord endothelial cell culture monolayer increased transendothelial albumin permeability significantly (P
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SINET: Ethiopian Journal of Science. ISSN: 0379-2897