ABSTRACT: Oral fructose administration has been demonstrated to stimulate the oxidation of alcohol. However, its influence on alcohol-induced hyperuricemia is yet to be documented. This study therefore, reports the effect of fructose on alcohol- induced increase in plasma urate in adult albino rabbits. Twelve male adult albino rabbits, divided into A, B and C experimental groups were purchased from Yoha Farms, Warri, Delta State. Group A, the control animals (n=4) were given normal saline, while Group B animals (n=4) orally received 1.5 g (40%) ethanol/kg body weight as single daily dose for a routine period of fifteen weeks. Group C rabbits (n=4) were treated in a similar manner but 0.25 g fructose/kg body weight was usually given after about 10 min of administering the ethanol dose. The results obtained show that ethanol administration significantly increased (P