Menstrual disorder is a common health problem among females in their reproductive years. It has psychosocial effects on the sufferer and her interactions with others during such periods. In Nigeria, menstrual disorder has received little research attention especially in the public health agenda. This study combines quantitative and qualitative approaches in investigating the prevalence of dysmenorrhoea and menorrhagia and their psychosocial effects by focusing on the daily activities of female undergraduates at the Obafemi Awolowo University, Ile-Ife, Nigeria. A multi-stage sampling technique was employed to select 415 female undergraduates at the University. A snowball sampling technique was used in selecting 37 informants for the in-depth interviews. Results showed a high prevalence of dysmenorrhoea (64%) among respondents within 3 months prior to this study. Dysmenorrhoea was significant among female students who reported dizziness, headache, depression and irritation; and those whose menstrual disorder ever called for medical attention (P