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Published:
Oct 5, 2016DOI:
10.4314/tjpr.v15i9.5Keywords:
Article Details
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Main Article Content
Expression of Oct-4 in oncogenic miR-155-positive oral squamous carcinoma cells
Abstract
Purpose: To identify effective molecular diagnostic methods for oral squamous cell carcinoma (OSCC) to facilitate treatment of the disease in its initial stages.
Methods: To identify molecular markers, OSCC tissue samples were collected from cancer patients and healthy controls. CD44+ cells were sorted using quantitative real-time polymerase chain reaction (qRT-PCR). Immunohistochemistry and immunostaining experiments were performed to identify markers for OSCC.
Results: The qRT-PCR data confirmed the presence of oncogenic miR-155 in the OSCC samples. The immunohistochemical and immunostaining results confirmed the expression of Oct-4, an important target for the early diagnosis of OSCC, in oncogenic miR-155-positive OSCCs.
Conclusion: Detection of the expression of miR-155 and Oct-4, which are key molecular markers, may be useful in improving the early diagnosis of OSCC.
Keywords: CD44, oral squamous cell carcinoma, oncogenic miR-155, Oct-4
