Chronic hepatitis in Nigerian patients: a study of 70 biopsy-proven cases
DA Ndububa, OS Ojo, VA Adetiloye, MA Durosinmi, BJ Olasode, OC Famurewa, AO Aladegbaiye, OA Adekanle
Abstract
Background: Liver cirrhosis and hepatocellular carcinoma are known sequelae of chronic hepatitis. Early diagnosis and treatment of chronic hepatitis could delay or even abort progression to terminal liver disease.
Study design: Prospective study of 70 consecutive patients with features of early liver disease or discovered with HBsAg (or anti-HCV) during pre-employment and/or pre-donation screening at Ile-Ife, Nigeria. All the patients had liver biopsy and the histology evaluated with the Knodell Histological Activity Index.
Result: Fifty-three patients had symptomatic disease (M: F ratio, 1.5:1) while 17 were asymptomatic (M: F ratio, 3:1). The mean ages were 49.04 (SD ±16.78) and 29.82 (SD ±6.13) for the symptomatic and the asymptomatic patients respectively (P
Study design: Prospective study of 70 consecutive patients with features of early liver disease or discovered with HBsAg (or anti-HCV) during pre-employment and/or pre-donation screening at Ile-Ife, Nigeria. All the patients had liver biopsy and the histology evaluated with the Knodell Histological Activity Index.
Result: Fifty-three patients had symptomatic disease (M: F ratio, 1.5:1) while 17 were asymptomatic (M: F ratio, 3:1). The mean ages were 49.04 (SD ±16.78) and 29.82 (SD ±6.13) for the symptomatic and the asymptomatic patients respectively (P
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West African Journal of Medicine. ISSN: 0189-160X