Evaluation of POSSUM and P-POSSUM as predictors of mortality and morbidity in patients undergoing laparotomy at a referral hospital in Nairobi , Kenya

ORIGINAL ARTICLE


Introduction
Surgical audit has become an essential requirement in modern surgical practice for ensuring the quality of care(1).By evaluating the procedures used for diagnosis and treatment and to lower the risks of patients undergoing surgery, both individual surgeon and institutional outcome trends can be analyzed (1).
Audits are common quality indicator tools in hospitals in the developed countries but rarely done in many developing countries (2).Patients are therefore subjected to surgery without due consideration of factors that may complicate the outcomes of these operations.In such setups, crude morbidity and mortality rates are used as indicators of quality of care.However, these approaches may be misleading since lack of adjustments for different settings leads to erroneous results when outcomes of surgery are compared between different units and hospitals (3,4).In order to standardize surgical audit procedures, a number of scoring systems have been developed for the comparison of case mixes.
Evaluation of POSSUM and P-POSSUM as predictors of mortality and morbidity in patients undergoing laparotomy at a referral hospital in Nairobi, Kenya of POSSUM and P-POSSUM scoring systems in predicting post-surgical outcomes in patients undergoing laparotomy in a referral hospital in Nairobi, Kenya.Selection of the patients was done from the point of admission -emergency laparotomy patients were selected from the accident and emergency department while those who underwent elective laparotomy were recruited from different hospital wards.Patient data was collected from hospital files.Patients and their relatives provided further information during the consent process.The primary outcomes were the actual 30-day mortality rates for the overall group and for different risk strata (6,7).Actual (observed) deaths were then compared to predicted (expected) mortality generated using the POSSUM and P-POSSUM equations.The results were analyzed using linear and exponential methods as described by Hobson et al (8).Secondary outcomes included actual and predicted rates of morbidities (surgical site infection, electrolyte imbalance, burst abdomen, intestinal ob-struction, and fecal fistulas among others) for the same group of patients, as originally described by Copeland et al (5).Pre-operative scores were done as described by Copeland et al (5) using 12 physiological factors while 6 operative scores were made at the end of the operation.

Kenyatta
Predicted morbidity and mortality rates were calculated using both POSSUM and P-POSSUM equations as described by Wijesinghe et al (9).
The discrimination power and accuracy of POSSUM and P-POSSUM in predicting death was measured using the receiver-operating characteristic (ROC) curve.An area under the ROC curve of less than 0.7 show poor discrimination, that of between 0.7 and 0.8 indicates a reasonable discriminatory power while a value above 0.8 suggests perfect discrimination.Statistical analyses and ROC curve plotting were done using the SPSS Version 15.0 (SPSS, Chicago, IL, USA).The Hosmer-Lemeshow (H-L) goodness of fit test (10) was used to assess the differences between predicted and observed mortality rates for POSSUM and P-POSSUM.
A value of p ≤ 0.05 was considered statistically significant.

Discussion
The results of the present study using The POSSUM mortality score over-predicts mortality in this study by a factor of 3 using exponential analysis and by a factor of 5 using linear analysis.It overestimated mortality in the low risk group by a factor of 2-3 and by factor of 3-5 in the high-risk group.Wijesinghe et al.
(9) advocated for the use of exponential analysis in estimating risk using the POSSUM equation.However the "exponential" method of analysis and subgroup analysis were not clearly described in the original Possum publication (5).It was only later that Wijesinghe et al elaborated on the methods of analysis for POSSUM and P-POSSUM and the divisions used to categorise patients to high risk and low risk groups (9).In our study there was significant over-prediction of mortality, irrespective of the method of analysis used for POSSUM mortality.
In comparison, the P-POSSUM equation performed better in prediction with linear analysis.The overall O: E ratio was 0.67%.This produced an overall over prediction factor of only 1.5.It is important to note that P-POSSUM under predicated deaths in patients at low risk mortality group (<10%) O:E 1.2:1.This under prediction in the low risk group has also been observed by
Eight (4.8%) patients died.The overall predicted mortality of the study group was calculated at 16.7% using the POSSUM linear analysis method (table 1) and 50% using POSSUM exponential analysis (table 2).This gave an observed to expected (O:E) ratio of 0.29:1 and 0.2:1 respectively.When similar calculations were made using the P-POSSUM scheme, the predicted mortality was 7.2% (linear analysis) and 13.9% (exponential analysis) giving an Observed to Expected ratio of 0.67:1 and 0.4:1 as shown in tables 3 and 4 respectively.
Eighty seven patients (52%) developed post-operative complications.The overall predicted morbidity using POSSUM was 38% (linear analysis) and 62% (exponential analysis).These gave an observed to expected (O:E) morbidity ratio of 1.09:1 (linear analysis) and a ratio of 1:1 (exponential analysis) as shown in table 5 and table 6 respectively.
Hosmer-Lemeshow analysis did not show a significant lack of fit with the observed mortality when applied National Hospital (KNH) is the central referral and teaching hospital in Kenya.It is located in the city of Nairobi.Nairobi has an estimated population of about 3 million people.Patients undergoing laparotomy at the hospital are managed by a tier of doctors from interns, senior house officers, surgical residents, registrars to full time consultants in General Surgery.However, all surgeries are performed by the residents, registrars and consultants.The institution has the capacity to undertake major surgical procedures on a 24-hour basis.We conducted a single centre prospective study over a period of 6 months in patients undergoing laparotomy from the emergency unit and those admitted to the general surgical wards, intensive and high dependency units at KNH.A total of 166 patients, undergoing either elective or emergency surgery, and meeting the recruitment criteria, were enrolled in the study.
POSSUM and P-POSSUM as predictive tools in consecutive patients undergoing abdominal surgery at Kenyatta National Hospital have allowed a reasonable assessment of the "quality of laparotomy" at the institution.The actual mortality rate of 4.8% recorded in the study is comparable to post-laparotomy mortality rates in earlier studies.Yii and Ng (2) in Malaysia recorded a mortality rate of 6.1% while Bollschweiler et al (12) found a death rate of 5.8% in their post-gastrectomy cohort.The studies by Vather et al (13) and Khan et al. (14) report even lower rates of around 4%.

Table 2
POSSUM mortality using exponential analysis

Table 1 .
POSSUM mortality using linear analysis.Evaluation of POSSUM and P-POSSUM as predictors of mortality and morbidity in patients undergoing laparotomy at a referral hospital in Nairobi, Kenya Kimani MM 1,2 , Kiiru JN 3 , Matu MM 3 , Chokwe T 1,2 , Saidi H 1,2

Table 4 :
P-POSSUM scores comparison of observed and predicted mortality using exponential analysisThe ANNALS of AFRICAN SURGERY | www.sskenya.org The ANNALS of AFRICAN SURGERY • Volume 5 • January 2010 31 2. Yii MK, Ng KJ.Risk-adjusted surgical audit with the POSSUM scoring system in a developing country.Br J Surg 2002; 89: 110 -113.

Table 6 :
Comparison of observed and predicted morbidity using exponential analysis for POSSUM

Table 5 :
Comparison of observed and predicted morbidity using linear analysis for POSSUM morbidity