Biochemical assessement of liver enzymes in immunocompromised subjects – HIV/AIDS

Abstract

Aim: This study aims at the estimation of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and glutmyltransferase GGT (Liver enzymes) in Human immunodeficiency virus(HIV) and/or Acquired immune deficiency syndrome(AIDS) patients in parts of Edo State, Nigeria.

Method: A total of 50 HIV/AIDS positive patients and 50 HIV/AIDS negative subjects as controls were studied from January to September, 2014. The enzymes were assayed using standard biochemical method.

Result: The mean ±SD of Alkaline phosphatise for HIV/AIDS patients was significantly increased (p<0.005) when compared with the control subjects. There was no significant increase (p>0.05) in the mean ±SD of ALP, AST, GGT and CD4 of female HIV/AIDS positive patients when compared with male subjects. Also, there was no significant increase (p>0.05) in the mean ±SD of ALT, AST and GGT of male HIV/AIDS positive patients when compared with male control subjects. There was a significant increase (P<0.05) in the mean ±SD of ALP of male HIV/AIDS positive when compared to male control subjects. There was a significant increase (p<0.05) in the mean ±SD of ALP and ALT of female HIV/AIDS positive when compared with female control subjects.

Conclusion: The routine testing for ALP and ALT, in HIV/AIDS patients is advocated based on results of this study.

Keywords: Assessment, Liver, Enzymes, HIV/AIDS