Annals of Biomedical Sciences

Log in or Register to get access to full text downloads.

Remember me or Register

DOWNLOAD FULL TEXT Open Access  DOWNLOAD FULL TEXT Subscription or Fee Access

Biochemical assessement of liver enzymes in immunocompromised subjects – HIV/AIDS

O.M. Omorogieva, D.J. Jemikalajah, G.R.A. Okogun


Aim: This study aims at the estimation of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and glutmyltransferase GGT (Liver enzymes) in Human immunodeficiency virus(HIV) and/or Acquired immune deficiency syndrome(AIDS) patients in parts of Edo State, Nigeria.

Method: A total of 50 HIV/AIDS positive patients and 50 HIV/AIDS negative subjects as controls were studied from January to September, 2014. The enzymes were assayed using standard biochemical method.

Result: The mean ±SD of Alkaline phosphatise for HIV/AIDS patients was significantly increased (p<0.005) when compared with the control subjects. There was no significant increase (p>0.05) in the mean ±SD of ALP, AST, GGT and CD4 of female HIV/AIDS positive patients when compared with male subjects. Also, there was no significant increase (p>0.05) in the mean ±SD of ALT, AST and GGT of male HIV/AIDS positive patients when compared with male control subjects. There was a significant increase (P<0.05) in the mean ±SD of ALP of male HIV/AIDS positive when compared to male control subjects. There was a significant increase (p<0.05) in the mean ±SD of ALP and ALT of female HIV/AIDS positive when compared with female control subjects.

Conclusion: The routine testing for ALP and ALT, in HIV/AIDS patients is advocated based on results of this study.

Keywords: Assessment, Liver, Enzymes, HIV/AIDS

AJOL African Journals Online