Demographic profile and epidemiology of injury in Mthatha , South

Objective: To determine the magnitude, socio-demographic and epidemiological characteristics of injury at a Provincial referral hospital. Methods: This review was conducted on all trauma patients admitted at the Mthatha Hospital Complex and Nelson Mandela Academic Hospital from the 1 January 1997 to the 31 December 2000. Results: The incident rate of injuries was 3.2% (n=2460/75,833 total admissions). Injured patients were mostly black (80%) and males (ratio: 5 men: 1 woman). Only 8.1% of injured patients were transported to hospital by ambulances. The leading causes of injuries were inter-personal violence accounting for 60% of cases, and motor vehicle accidents accounting for 19%; of them 38% were due to poor visibility, over speeding, and fatigue. The overall mortality was 33% (n=821) independently predicted by poverty (OR=8.2 95%CI 6-11.1; P<0.0001) and age>40 years(OR=7.8 95%CI 7.7-12.1;P<0.0001). Conclusion: The burden of injury is a mass issue that warrants regional attention with quality of care and training.


Introduction
It is well established that injury is an important public health problem and will be a serious threat to future generations worldwide [1][2][3][4][5] .In developing countries including South Africa, there is a high burden of injuries due to road-traffic accidents, excessive alcohol intake, substance abuse and interpersonal violence, with this latter problem being increasingly seen as a public health priority.However, funding and research to deal with this burden is lacking in comparison to allocations for malaria, tuberculosis and HIV/AIDS 6.About 50% of all admissions in the departments of surgery are due to injuries (trauma, homicide, suicide, transport accidents) contributing substantially to the injuries burden for those in poor and disadvantaged settings.In South Africa 7 and in Eastern Cape, the poorest province of South Africa in particular [8][9][10] , the burden of injury is huge because of road-traffic-accidents, interpersonal violence, excessive alcohol intake and substance abuse.Interpersonal violence is increasingly being seen as a public health priority (11); as such violence is a major cause of mortality and morbidity resulting not only in physical but also in psychological trauma.Furthermore, the absence of a valid injury surveillance system is a source of concern in South Africa [11][12][13][14] .
Therefore, the objective of this study was to determine the magnitude and the sociodemographic and epidemiological characteristics of injury.All consecutive referent cases admitted to the Accident and Emergency Units of Mthatha Hospital Complex were eligible and served as the origin population denominator to calculate the incidence of fresh injuries during the study period.The modes of admissions for all cases were as follows: self-referral, direct referrals from the peripheral hospitals, clinics, security departments and family practitioners from this part of the Eastern Cape Province.

This retrospective review was
On admission of injured patients, a structured and standardized questionnaire was completed by the admitting Medical Practitioner.The questionnaire obtained information on sociodemographic data (age, gender, ethnicity, marital status, socioeconomic status or SES), and epidemiological data (means of transportation to hospital, causes, areas and type of trauma , distance from the hospital to scene of injury, clinical evidence of alcohol use, diagnosis), and outcomes(mortality, disability and recovery).The management during hospital stay included complete physical examination by medical practitioners, routine clinical and laboratory investigations, and follow-up till discharge of patients.
The interval time from injury to treatment, surgical resource utilization(operation teams, materials), length of hospital stay, lost productivity and follow-up were recorded with the diagnosis obtained from physical examination combined with investigations (X-ray, CT Scan) respectively.

Statistical analysis
Statistical Package for Social Sciences (SPSS) version 20.0 for Windows (SPSS Inc., Chicago, IL, USA).Mean, standard deviation and 95% confidence intervals(CI) of age, univariate relative risk(RR) and multivariate odds ratio(OR) and their 95% CIs were assessed for association between determinants and mortality by chi-square test and logistics regression model, respectively.

Definitions
Ethnicity was defined according to historical races; Black, Asian, Coloured (mixed race), and Caucasian (White).Children, adolescents and young adults were aged <40 years versus old individuals aged >40 years.Marital Status comprised married and single persons.Lost productivity in the employed was defined by a substitute (proxy) variable which was the time when the patient did not work for >7 weeks (Tertile 2 and Tertile 3 of the variable in the study).Low SES (Poverty) was defined by without income vs. high SES with income.Golden Hour -Early management, intermediate Hour management, and delayed Hour management defined by <1 Hour, 1-6 Hours, and > 6 Hours respectively.Longer length of hospital stay was defined by additional >5 days (Median).

Incidence of Injury
Out of a total of 75833 patients admitted to the Accident and Emergency Units (eligible population), 3.2% (n=2460) or 32 per 1000 persons defined the incidence rate of injuries between 1997 and 2000.

Causes of injury
Amongst the major causes contributing to injury were interpersonal violence (the leading cause in terms of 2 to 3 injured), motor vehicle accidents (out of those 468 accidents, 38% [n=178] were due to poor visibility, over-speeding or fatigue, and 62% [n=290] were due to alcohol consumption).

Area of incident
The largest proportion of injuries occurred in the open fields (44.3%), followed by drivers involved in motor vehicle accidents (22.4%), pedestrians on the road (17%), and accidents in workplaces (16.3%).The leading areas of incidents were interpersonal violence in the veld (patients who were injured in outlying rural areas outside the urban/ peri-urban areas) and were transported into the hospital followed by Road Traffic Accidents (RTA) which contributed for 44.3%and 39.4% respectively.

Discussion
The present study aimed at collecting and analyzing injury-related documentation in the Eastern Cape Province of South Africa.

Incidence of injuries
It was important to know the incidence of injury because of its high socio-economic consequences, short-term as well as long term.The burden of injury in the most impoverished province of South Africa was invisible before the present study.The incidence rate of injury was estimated at 32 for 1000 persons, a finding higher than 5.2 -21.7 per 1000 persons admitted to casualty units in six developed European Countries 15 , but similar to those from developing countries 16 .This large difference between countries reflects different levels of knowledge and control of injury clearly pointing to the poor injury surveillance, coupled with high rates of injury in developing countries 17 .

Characteristics of injury
Socio-demographic variables such as male gender, age <40 years, single status, poverty, and black were identified with the highest absolute risk of injury in this region.These findings suggest the presence of inequalities in wealth and health within the province despite the efforts of the South African Government to reduce this after apartheid was eliminated in 1994 18 ).
The present socio-demographic distribution of injury is in agreement with those reported worldwide [19][20][21][22] .Males were more vulnerable than females [19][20][21][22] .Younger, black, single, and unemployed were the most affected.The findings reflected the underlying demographic and economic patterns in sub-Saharan Africa, with a relatively younger population compared to developed countries.

Area, causes and mechanisms of injury
Road Traffic Accidents, interpersonal violence (Assault) in open fields, and motor vehicle accidents, were mostly observed.The exceptional high burden from injuries associated with violence and road traffic accidents is characteristic of other settings of South Africa 7 and East Africa 20 .The prominent role of homicide is well established in interpersonal violence-related injuries in all South Africa because of the apartheid legacy, disintegration of the social fabric, poverty, and gender inequalities 7 .
Open fields were the facilitating factor for interpersonal violence including the use of firearms, while alcohol/substance use, speeding of cars and fatigue were the leading facilitating factors of Road Traffic Accidents [7][8][9][10][11]23 .
The burden of morbidity and mortality in limited income countries is increasing due to clustering of rapid urbanization, industrialization, motorization, poor roads, low visibility, inadequate traffic infrastructure and speeding behavior of drivers 24 .Both drivers and pedestrians were equally affected.However, in other developing countries settings, pedestrians and passengers are the common victims of road traffic accidents 24 .
The present findings contrast with reduced injuries and motor vehicle accident deaths in technologically advanced countries 25 .

Diagnosis of injury
Analysis of the proportions of injury to different anatomical sites of the body showed that head Injury was the most frequently seen accounting for almost double of the mean combination of the rest of injured anatomical areas of the body.Head injury, abdominal injury and chest injury were defined by severe penetrating wounds prone to infections.Those severe injuries were due to gunshots from robbers, communal skirmishes and cultists with a desire to kill, while extremity injuries are from police with a desire to immobilize those armed gangs 26 .

Outcomes
The outcomes of this study were defined by surgical resource utilization including operation, longer hospitalization and deaths estimated at 29.1%, 31.3% and 33%, respectively.This suggests that the injuries were major in severity and influenced by the prehospital phases (Pre-event, event and post-event phase) (Intra-hospital and post-hospital periods) 27 .The present injury related mortality is similar to 31.8%rate reported in hospitals from developing countries including South Africa, but higher than 23.78%rate observed in hospitals from developed countries 7 .This high rate of deaths from injuries may be explained by the huge extent of poverty, age>40 years, male predominance, traffic road, violence,lack of skills in first aid to modes of transportation to hospital, care quality and access as reported in the Eastern region of Africa.

Economic impact
Injury was responsible for uncalculated cost to the government because of long hospital stays, an important proportion of occupational injuries, and lost productivity due to longer time of absenteeism in employed patients.

Conclusion
Injury incidence and death rates among injured are high in the Eastern Cape Province of South Africa.
Action is urgently needed at pre-event, event, and post-event stages in terms of prevention, improved management, rehabilitation, training of health professionals, and research capacity building.
conducted from 1 st January 1997 to 31 st December 2000.Ethical approval was obtained from the Walter Sisulu University (WSU) Ethical Committee to conduct the study.Mthatha Hospital Complex including Mthatha General Hospital and Nelson Mandela Academic Hospital of WSU was chosen as the study setting for various reasons.Mthatha Hospital Complex is the main referral health facility for the eastern part of Eastern Cape.It caters for Level 2 and 3 services to this part of the province with 6 million people.It serves as a teaching hospital for WSU.It is also situated in Mthatha municipality approximately 150 meters off the National Road (N2 Highway) that links the cities of East London and Durban.