Synergistic effect of aqueous extract of Telfaria occidentalis on the biological activities of artesunate in Plasmodium berghei infected mice

  • OM Adegbolagun
  • BO Emikpe
  • IO Woranola
  • Y Ogunremi

Abstract

Background: Resistance to most antimalarial drugs has encouraged the use of herbal preparations along with prescribed orthodox drugs.
Objective: To investigate effect of co-administration of aqueous extract of T. occidentalis leaves; commonly used as antimalarial and haematinic agent in Nigeria and artesunate using P. berghei animal model.
Methods: In vivo curative antiplasmodial effect of T. occidentalis (200mg/kg) alone and combination with artesunate (2mg/kg) were evaluated using albino mice infected with 106 parasitized erythrocytes of P. berghei intraperitoneally. The haematological parameters: haemoglobin level, red blood cells and white blood cells and packed cell volume were monitored using standard methods.
Results: Aqueous extract of T. occidentalis, artesunate and the combination gave 72.17±4.07%, 70.43± 4.27% and 85.43± 3.65% reduction in parasitaemia after 48hours respectively. A significant enhancement of the PCV was obtained with the coadministration of artesunate and aqueous extract (p< 0.01). Similar trends were also observed with heamatological parameters at 72hours of administration.
Conclusion: This study revealed a synergistic effect of the co-administration on parasite clearance rate of P. berghei infection in mice, with a significant enhancement of haematological parameters within 48 hours of administration. This indicates a rapid rate of recovery from plasmodial infections with the co-administration.

African Health Sciences 2013; 13(4): 970 - 976

Author Biographies

OM Adegbolagun
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Ibadan
BO Emikpe
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria
IO Woranola
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ibadan, Ibadan
Y Ogunremi
Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmacy, University of Ibadan, Ibadan
Published
2014-01-30
Section
Articles

Journal Identifiers


eISSN: 1680-6905