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Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia

AGB Azebaze, JEM Teinkela, EL Nguemfo, A Valentin, AB Dongmo, JC Vardamides

Abstract


Background: Plasmodium falciparum, one of the causative agents of malaria, has high adaptability through mutation and is resistant to many types of anti-malarial drugs. This study presents an in vitro  assessment of the antiplasmodial activity of some phenolic compounds isolated from plants of the genus Allanblackia.

Methods: Tests were performed on well plates filled with a fixed parasitized erythrocytes volume. Compounds to be tested were then added in wells. After incubation, tritiated hypoxanthine is added and the plates were returned to the incubator. After thawing, the nucleic acids are collected. Inhibitory Concentration 50 (IC50) was determined by linear interpolation.

Results: From Allanblackia floribunda, have been isolated and characterized 1,7-dihydroxyxanthone 1, macluraxanthone 4, morelloflavone 9, Volkensiflavone 10 and morelloflavone 7-O-glucoside 11; from Allanblackia monticola, α-mangosine 2, rubraxanthone 3, allaxanthone C 5, norcowanine 6 , tovophiline A 7, allaxanthone B 8 and from Allanblackia gabonensis, 1,7-dihydroxyxanthone 1. Six of them were  evaluated for their antimalarial properties. The most active compound, macluraxanthone, presented a  very interesting activity, with an IC50 of 0.36 and 0.27 μg/mL with the F32 and FcM29 strains  respectively.


Conclusion: This work confirms that species of Allanblackia genus are medicinally important plants containing many biologically active compounds that can be used effectively as antiplasmodial.


Key words: Guttiferaceae, Allanblackia, Phenolic compounds, Antiplasmodial activity




http://dx.doi.org/10.4314/ahs.v15i3.18
AJOL African Journals Online