Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease

  • Jia-Jun Ye
  • Tian-Biao Zhou
  • Yun-Fang Zhang
  • Qi Wang
  • Yan-Yan Su
  • Jia-Min Tang
  • Hong-Yan Li
Keywords: Vitamin D receptor (VDR), CYP24A1, end-stage renal disease (ESRD)

Abstract

Objective: This study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls.

Method: In this study, 24 ESRD patients and 24 healthy controls were included.

Results: In our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20±0.32 vs 8.59±1.03; P﹤0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from healthy controls (50.18±21 vs 7.78±1.31; P﹤0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=-0.723; P﹤0.01).

Conclusion: VDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1.

Keywords: Vitamin D receptor (VDR), CYP24A1, end-stage renal disease (ESRD)

Published
2016-07-01
Section
Articles

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eISSN: 1680-6905