Polysaccharides obtained from mycelia of Cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy

  • Ruo-Kai Lin
  • Chen-Yen Choong
  • Wei-Hsuan Hsu
  • Chen-Jei Tai
  • Cheng-Jeng Tai
Keywords: Cordyceps militaris, traditional Chinese medicine, doxorubicin, chemotherapy, immunotherapy.

Abstract

Objectives: Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy.
Methods: Doxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells.
Results: PS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells.
Conclusion: These findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.

Keywords: Cordyceps militaris, traditional Chinese medicine, doxorubicin, chemotherapy, immunotherapy.

Published
2019-08-21
Section
Articles

Journal Identifiers


eISSN: 1680-6905