Characteristics and outcomes of patients with multiple myeloma at the Uganda Cancer Institute

  • Clement D Okello
  • Yusuf Mulumba
  • Abrahams Omoding
  • Henry Ddungu
  • Kristen Welch
  • Cheryl L Thompson
  • Andrew J Cowan
  • Matthew M Cooney
  • Jackson Orem
Keywords: Multiple myeloma; Uganda cancer institute.

Abstract

Purpose: Data on multiple myeloma (MM) in sub-Sahara Africa is scarce. In Uganda, there is a progressively increasing incidence of MM over the years.

Methods: We performed a retrospective study on 217 patients with MM at the UCI using purposive sampling method. The objectives of the study were to determine the clinical characteristics, treatment outcomes, 5 year overall survival and predic- tors of survival of patients with MM at the UCI from 01 January 2008 to 31 December 2012.

Results: There were 119 (54.8%) males; the mean(SD) age of the study population at presentation was 59(12.8) years; 183(84.3%) patients presented with bone pain, and 135 (61.9%) had skeletal pathology; 186(85.3%) were HIV negative, and 152(70%) had Durie-Salmon stage III. The median overall survival was 2.5 years, (95% CI, 0.393-0.595); factors significantly associated with worse survival were Durie-Salmon stage III disease, HR=5.9, 95% CI (1.61 – 21.74; P=0.007) and LDH >225 U/L HR=3.3, 95% CI (0.57 – 5.92; P=0.029).

Conclusion: Most patients with multiple myeloma at the UCI were diagnosed at a relatively young age, presented with late stage disease and bone pain, and had a shorter survival time. Factors associated with worse survival were Durie-Salmon stage III and LDH >225 U/L.

Keywords: Multiple myeloma; Uganda cancer institute.

Published
2021-04-16
Section
Articles

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eISSN: 1680-6905