Main Article Content

Early detection of Pre-XDR TB with line probe assay in a high TB burden country


Laura Madukaji
Isaac Okohu
Saheed Usman
Uche Oyedum
Abdullah Enagi
Abubakar Usman
AS Adedeji
Femi Owolagba
Eke Ofuche
Jay Osi Samuels
Toyin Jolayemi
Prosper Okonkwo

Abstract

Background: Worldwide, tuberculosis (TB) is one of the top 10 causes of death. Drug resistant tuberculosis has lately become a major public health problem that threatens progress made in Tuberculosis (TB) care and control worldwide. The aim of this study was to determine the prevalence of Pre-extensive drug resistant TB among MDR TB in North Central of Nigeria.


Methods: This study was conducted from October, 2018 to August, 2019 with 150 samples. In Nigeria, guidelines for DR-TB as recommended by WHO is followed. All the samples from the patients who gave their consent were transported to a zonal reference TB laboratory (ZRL).


Results: Mean age was 38.6 ± 13.4 years with peak age at 35-44. Out of these 103 samples processed with LPA, 101(98%) were rifampicin resistant and 2 were rifampicin sensitive, 99(96%) were INH resistant and 4 (4%) were INH sensitive, 5(5%) were fluoroquinolone resistant, 98(95%) were fluoroquinolone sensitive, 12 (12%) were Aminoglycoside + Capreomycin resistant, 91(83%) were Aminoglycoside + Capreomycin sensitive.


Conclusion: Multidrug resistant TB and its severe forms (Pre-extensive & extensively drug resistant TB) can be detected early with rapid tool- Line Probe Assay rapid and prevented timely by early initiation on treatment.


Keywords: Pre-XDR TB; line probe assay in a high TB burden country.


Journal Identifiers


eISSN: 1729-0503
print ISSN: 1680-6905