Evaluation of patients with Crimean-Congo hemorrhagic fever in Bolu, Turkey

  • A Duran
  • A Küçükbayrak
  • T Ocak
  • NI Hakyemez
  • T Taþ
  • M Karadað
  • ZF Mengeloðlu
Keywords: Black Sea, Crimean-Congo hemorrhagic fever virus


Background: Crimean-Congo hemorrhagic fever (CCHF), which is  associated with a high mortality rate in the Black Sea region of Turkey, has received increasing attention.
Objective: In this study, the epidemiological features, clinical and  laboratory findings, treatments, and outcomes of patients diagnosed with CCHF between 2006 and 2012 based on data obtained from the Bolu  Provincial Directorate of Health (BPDH) were evaluated.
Methods: BPDH data were reviewed for the period between 1 January 2006 and 31 July 2012. The locations where the tick had attached to the patient, the site of the tick bite on the patient’s body, the dates of tick bite and removal, and the demographic characteristics of each patient were  recorded. BPDH data on the total number of tick bites, patients with confirmed CCHF, and deaths due to CCHF in Bolu Province during the study period were also evaluated.

Results: A total of 46 patients with CCHF and 38 patients without CCHF but who had been bitten by ticks were admitted to the BPDH. Of the patients with CCHF, 54.3% were female. The mean age of the patients was 46.88 ± 2.05 years (range, 1–79 years). The mortality rate was 8.82%. Patients were predominantly observed in June and July. When the patients were distributed according to their occupations, the majority was houswife  (48.6%), followed by animal husbandry worker (27.0%), farmer (10.8%), health worker (5.4%), and other (8.1%). The symptoms of the patients with CCHF included fatigue (60.9%), fever (60.9%), and myalgia (60.9%). Of those patients with CCHF, 41.3% were determined to have a high
Conclusions: The probability of developing CCHF decreased as the  duration of tick attachment increased. Moreover, although the clinical presentation is important, it is not diagnostic. Physical examination and laboratory findings become more specific in later stages.

Keywords: Black Sea, Crimean-Congo hemorrhagic fever virus


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eISSN: 1680-6905