Disseminated Histoplasmosis in a 13-year-old girl: A case report

  • AC Ubesie
  • OC Okafo
  • NS Ibeziako
  • VO Onukwuli
  • NR Mbanefo
  • JC Uzoigwe
  • C Bede
  • BC Ibe
Keywords: Disseminated histoplasmosis, immune-competent, adolescent girl, Enugu


Background: Disseminated histoplasmosis is a rare fungal infection and most documented cases are in immunecompromised individuals such as those with acquired immuno-deficiency syndrome.
Objective: To describe a case of disseminated histoplasmosis in an adolescent girl.
Method: We report a case of disseminated histoplasmosis in a 13-year-old adolescent girl. She was admitted for 16 days because of neck masses of 3 years duration, generalized body swelling of 3 months and reduction in urinary output of 2 months. She tested negative for human immunodeficiency virus antibodies.
Result: An autopsy was performed because a definitive diagnosis could not be made while the patient was still alive. The autopsy revealed central caseating areas in the lymph nodes and membranoproliferative  glomerulonephritis. The periodic acid-Schiff staining technique for tissues showed viable yeast cells suggestive of histoplasmosis. Zeihl-Neelsen’s staining for mycobacteria tuberculosis was negative.
Conclusion: Undiagnosed case of disseminated histoplasmosis while the patient was alive is being reported in a 13-yearold girl. Disseminated histoplasmosis should be considered as a differential diagnosis of  childhood chronic infections and malignancies as in Nigeria.

Key words: Disseminated histoplasmosis, immune-competent, adolescent girl, Enugu


Journal Identifiers

eISSN: 1729-0503
print ISSN: 1680-6905