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Manumycin from a new <i>Streptomyces</i> strain shows antagonistic effect against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)/vancomycin-resistant enterococci (VRE) strains from Korean Hospitals


Yun Hee Choi
Seung Sik Cho
Jaya Ram Simkhada
Chi Nam Seong
Hyo Jeong Lee
Hong Seop Moon
Jin Cheol Yoo

Abstract

An antimicrobial compound, highly effective against multidrug-resistant (MDR) bacteria, purified from a Streptomyces strain was identified as manumycin. The minimal inhibitory concentrations (MICs) of manumycin against 8 different strains of methicillin-resistant Staphylococcus aureus (MRSA) were ranged 2 to 32 μg/ml. Similarly, MICs of manumycin against 4 vancomycin-resistant enterococci (VRE) strains were ranged 8 to 32 μg/ml while it remained ineffective against 4 other VRE strains. Compared to vancomycin, manumycin provided slightly weaker activity against MRSA strains but stronger activity against 4 VRE strains. This is the first report of antagonistic effect of manumycin against MDR pathogens.

Keywords: Manumycin, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE)

African Journal of Biotechnology Vol. 12(17), pp. 2249-2253

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eISSN: 1684-5315