The adverse reaction of chitooligosaccharides in rats
In this study, hair removal effect after subcutaneous injection of chitooligosaccharides in mice was investigated. Different methods of observation of hair removal, tissue slices and detection of hematological parameters, like aminacridone (AMAC) labeled and antagonism treat were employed in this research. It was shown that Chitooligosaccharides exhibited renal toxicity, which was similar to aminoglycoside antibiotics (AmAn) toxicity.
Key words: Chitooligosaccharides, adverse reaction, nephrotoxicity, in vivo metabolism, antagonism.