Anti-toxoplasma gondii activity of constituents from Balsamocitrus camerunensis L (Rutaceae)

  • EN Happi
  • EJT Mbosso
  • EL Nguemfo
  • HR Zambou
  • AGB Azebaze

Abstract

Isolation, characterization and anti-Toxoplasma gondii activity of constituents from the CH2Cl2/MeOH (1/1) extract of the roots of the cameroonian plant Balsamocitrus camerunensis L. were investigated in this study. Four known coumarins derivatives were isolated, namely, marmin (1), imperatorin (2), xanthoxyletin (3), 6,7-Dimethoxycoumarin (4) and an acridone derivative namely 1-hydroxy-3-methoxy-acridone (5). Their structures were established on the basis of their spectroscopic data compared to reported results. Some of the isolated compounds showed noteworthy activity against Toxoplasma gondii intracellular parasite in mammals with an inhibition of parasite growth of around 46.44% for compound 4 and 82.12% for compound 3 which was the most active compound.

Keywords: Balsamocitrus camerunensis, Rutaceae, coumarins, alkaloid, toxoplasmacidial activity.

African Journal of Biotechnology, Vol 13(52) 4680-4684

Author Biographies

EN Happi
Laboratoire de Chimie bio-organique, analytique et structurale, Departement de Chimie, Faculte des Sciences, Universite de Douala, BP 24157 Douala, Cameroon
EJT Mbosso
Laboratoire de Chimie bio-organique, analytique et structurale, Departement de Chimie, Faculte des Sciences, Universite de Douala, BP 24157 Douala, Cameroon
EL Nguemfo
Laboratoire de Chimie bio-organique, analytique et structurale, Departement de Chimie, Faculte des Sciences, Universite de Douala, BP 24157 Douala, Cameroon
HR Zambou
Laboratoire de Chimie bio-organique, analytique et structurale, Departement de Chimie, Faculte des Sciences, Universite de Douala, BP 24157 Douala, Cameroon
AGB Azebaze
Laboratoire de Chimie bio-organique, analytique et structurale, Departement de Chimie, Faculte des Sciences, Universite de Douala, BP 24157 Douala, Cameroon
Published
2015-11-16
Section
Articles

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eISSN: 1684-5315